Latest FocusAutomated ink-removal system for blinding clinical trial materials(Free)Among the methods used to blind clinical trial materials, removal of identifying ink from the surface of dosage forms is not commonly employed because it is very laborious. Recently, however, an automated system for de-inking was developed. This article describes the results of a study that evaluated how this automated system compares to a manual process in terms of the extent of ink removal and the effects on the drug product surface.Assessing how the physical properties and enhanced powder flow of HPMC affect process control during direct compression of matrix tabletsThis article describes a study that investigated a new direct-compression grade of HPMC alongside a control. The study characterized the differences in the physical properties of the two HPMCs and assessed whether those differences—as well as flow performance—translated into differences in the processability of matrix tablets.General FeaturesNon-destructive options for leak-testing blister packagesConcerns about waste, human error, and cGMP compliance are leading some packaging facilities to seek alternatives to the standard blue-dye leak test for blister packaging.Meeting the challenges of producing ultra-potent, high-count probioticsOne way to capture consumer interest in a probiotic health supplement is to offer a product loaded with multiple microbial strains in large concentrations per dose. In this article, the authors discuss the special challenges of formulating, manufacturing, and handling these ultra-potent probiotics and offer advice on overcoming them.Eye on Excipients: Low-viscosity HPCsGuest columnist Ryan Cheng describes the application and benefits of using special low-viscosity hydroxypropyl cellulose (HPC) to formulate immediate-release (IR) tablets and films and improve the solubility of actives.