Latest FocusUsing terahertz spectroscopy to map tablet cores and coatings(Free)Terahertz technology provides a non-destructive way to characterize solid dosage forms by measuring the crystallinity and polymorphism of constituent APIs, the spatial uniformity of layers and coatings, and the density and porosity of compacts. Terahertz analysis is fast and requires little or no sample preparation. It is suitable for R&D, routine QA/QC, and process analytical technology (PAT) applications.Quality by Design’s impact on the cost of drug developmentMany people agree that implementing Quality by Design should lead to better drug products. But does the approach help or hurt profitability? This article outlines a model for understanding how QbD affects costs and how to maximize the return on investment in implementing QbD.Selecting a vibratory sieve to check-screen highly potent powdersSieves have undergone major design changes to meet the demands of pharmaceutical manufacturers for easier and faster cleaning, better product quality and, most important, more features to preserve the health and safety of operators. This article describes those improvements, with a particular focus on how today’s sieves improve operator safety by containing powders to ensure compliance with occupational exposure limits (OELs).Measuring bulk density: Advantages of a shear cellThis article summarizes why it’s better to use a shear cell instead of a tapping mechanism and a graduated cylinder.General FeaturesSpotlight on Nutraceuticals: Soft or hard, liquid-filled capsules find niche in nutra marketPharmaceutical formulators are increasingly turning to liquid-filled capsules to improve drug delivery. This article looks at how—and why—dietary supplement and nutraceutical manufacturers use liquid fills, too.
Eye on Excipients: FDASIA’s effect on excipientsMembers of IPEC-Americas discuss how some provisions of FDASIA might affect the manufacture and supply of excipients, and thus the manufacture and supply of drug products. They also provide several recommendations for improvement.
Back Page: You can’t correct for randomness(Free)Continuous correcting, revising, and tweaking can spell process doom when made to stable systems that are operating within statistical control.