Delves into all aspects of R&D and manufacturing of all oral solid dose (OSD) forms. Tracks industry trends. Relays latest applied research relevant to OSDs. Provides “how to” information for the latest techniques in formulation/excipients, tablet manufacturing, capsule filling and other aspects of the process—including logistics like supply-chain management.
The first consideration before coating begins is core shape. A flat profile, for example, is a poor choice because it will allow many of the tablets to stick together, a defect called twinning. The ...
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Film coating materials are expensive, and wasting them just adds to their cost. Nonetheless, very few companies compare the amount of solids sprayed with the weight gain of coated products. Nor do ...
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When applying a coating, the goal is to modify the surface properties of tablets or particles. Pharmaceuticals are often coated to protect them from the effects of exposure to water or moisture. In ...
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Academics and medical professionals acknowledge the benefits of dietary supplements—at least some of them— and many physicians even recommend them. Nonetheless, the dietary supplement industry is ...
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The pharmaceutical industry’s interest in bi-layer tablets has grown because they promote patient convenience and compliance. They do so by combining multiple active pharmaceutical ingredients (APIs) ...
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Leaking gelatin capsules diminish consumer confidence in the product and the manufacturer. To prevent defective capsules from reaching the market, you must develop tests to identify them. One approach...
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The pharmaceutical industry is as strict as it comes in terms of demanding quality products and procedures. And rightfully so, because that never-satisfied outlook helps ensure confidence in the ...
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There are more than 100 different coatings used on tablets and capsules. While many have a biological effect—enteric coatings or controlled- release coatings that delay releasing the active(s)—others ...
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Big political change is remaking previous certainties, and people of all political views can see that healthcare is going to change. One early attempt—repealing or amending the Affordable Care Act (...
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Segregation can be a serious issue when a blend of multiple powders is fed to a tablet press, capsule filler, or other process equipment. This is especially true when the blend contains an API whose ...
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The nutraceutical benefits of medium-chain triglycerides (MCTs) are well known. The primary benefit: MCTs are quickly converted in the liver to energy-providing ketone bodies like beta-hydroxy ...
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Tablets and capsules have long been the primary platforms for reliable delivery of safe, efficacious pharmaceutical products. Compressed tablets originated in England in the early 1840s, and the use ...
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Content uniformity of the active pharmaceutical ingredient (API) in tablets is critical because it ensures patients receive the same dose from tablet to tablet. But it becomes increasingly difficult ...
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Since the Dietary Supplement Health and Education Act (DSHEA) became law in 1994, companies have needed to prove the safety of their dietary supplement ingredients before products reached the market.
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For manufacturers, downtime is a necessary evil. It’s when production stops so you can clean and maintain your machinery and change over the tooling. Ideally, downtime would be scheduled and occur ...
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