Ardelyx, Inc. announced multiple presentations covering additional positive clinical observations of XPHOZAH at the National Kidney Foundation 2022 Spring Clinical Meetings (NKF SCM2022). Ardelyx has completed three successful Phase 3 pivotal trials, and two additional Phase 4 clinical trials (OPTIMIZE and NORMALIZE) for XPHOZAH, an investigational, first-in-class, phosphate absorption inhibitor for the control of serum phosphorus in adult patients with chronic kidney disease (CKD) on dialysis. XPHOZAH was discovered and developed by Ardelyx.
"The responder analysis from the PHREEDOM trial, the onset of action analysis from the Phase 3 program, and new data generated from our Phase 4 studies further build on the body of evidence that support the potential role that XPHOZAH, as a first-in-class phosphate absorption inhibitor, could play in the management of hyperphosphatemia," said Laura Williams, M.D., M.P.H., chief medical officer for Ardelyx. We continue to pursue approval of XPHOZAH and believe this novel treatment option represents an important innovation for patients and providers in the nephrology community."