Positive long-term follow-up results from the PAOLA-1 and SOLO-1 Phase III trials of LYNPARZA® (olaparib), jointly developed and commercialized by AstraZeneca and Merck & Co., Inc., known as MSD outside the US and Canada, with or without bevacizumab demonstrated clinically meaningful improvements in overall survival (OS). Further results showed class-leading progression-free survival (PFS) in combination with bevacizumab for homologous recombination deficiency (HRD)-positive patients, versus active comparator, bevacizumab, and as monotherapy for patients with BRCA mutations, versus placebo, respectively.
Both trials which were conducted in biomarker-selected, newly diagnosed patients with advanced ovarian cancer in the 1st-line maintenance setting also demonstrated a consistent safety profile.1,2
The results for PAOLA-1 (Abstract #LBA29) and SOLO-1 (Abstract #517O) were presented on September 9 at the 2022 European Society of Medical Oncology (ESMO) and SOLO-1 results were published in the Journal of Clinical Oncology.