Rani Therapeutics Holdings, a clinical-stage biotherapeutics company, announced that it has partnered with Celltrion for the development of RT-111, an orally administered ustekinumab biosimilar.
Under a license and supply agreement, Celltrion will exclusively supply to Rani the ustekinumab biosimilar drug substance (CT-P43) required for RT-111. Rani is granted an exclusive license to use CT-P43 in the development and commercialization of RT-111, and Celltrion is granted a right of first negotiation to acquire worldwide rights to RT-111 following a Phase 1 clinical trial.
Rani has developed an oral delivery technology known as the RaniPill™ capsule, which is intended to replace subcutaneous or intravenous injection of biologics and drugs with oral dosing. The RaniPill™ capsule is designed to administer biologics and drugs with bioavailability comparable to subcutaneous injection.