Accord Healthcare, a generic pharmaceutical company, has added Teriflunomide to its portfolio of oral medications. The drug is formulated as a film-coated tablet. Accord's Teriflunomide is therapeutically equivalent to Sanofi Genzyme's Aubagio® and is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.
Teriflunomide is approved by the FDA for use as an immunomodulatory agent in patients 18 and older to decrease the frequency and severity of disease flare-ups, called relapses, to prevent new symptoms or a worsening of old symptoms related to the disease's neurologic impact.
Teriflunomide belongs to a class of drugs known as immunomodulatory agents or disease-modifying therapy. It works by inhibiting an enzyme essential to a biochemical pathway involved in the proliferation of lymphocytes, a type of white blood cell. Fewer activated lymphocytes reduces inflammation and immune reactivity to reduce relapse rates and to protect against brain volume loss resulting from inflammatory attacks on the nerve cells in the brain.
Teriflunomide was first approved by the FDA in 2012.