Delves into all aspects of R&D and manufacturing of all oral solid dose (OSD) forms. Tracks industry trends. Relays latest applied research relevant to OSDs. Provides “how to” information for the latest techniques in formulation/excipients, tablet manufacturing, capsule filling and other aspects of the process—including logistics like supply-chain management.
The self-emulsifying drug delivery system (SEDDS) is one of the most viable options for enhancing the bioavailability of poorly soluble active pharmaceutical ingredients (APIs). SEDDS consist of ...
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Modern tablet coaters must be able to handle tablets and other dosage forms with a wide range of formulations, shapes, and sizes and using a variety of coating solutions. Solvent-based coating ...
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In February of 2019, the FDA requested proposals for pilot projects to demonstrate an electronic interoperable system for the confidential track and trace of pharmaceuticals throughout the supply ...
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About 90 percent of API molecules in the discovery pipeline are water insoluble, contributing to bioavailability challenges.
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Parsolex is a contract development and manufacturing services organization (CDMO) that works with clients involved in the research, development, and commercialization of non-sterile pharmaceutical ...
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Some companies operating slat fillers try to use one set of slats for many different products. However, slats should generally be product specific.
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Hard capsules are traditionally composed of pure gelatin and water and are available in a wide variety of shapes, sizes, and colors. Consumers find them easy to swallow, and industry prefers them ...
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For experts in lean manufacturing, batch processing is sub-optimal. One-piece flow represents the ideal—a widget created as the customer demands it, satisfying the customer, optimizing the company’s ...
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Up to 70 percent of active pharmaceutical ingredients (APIs) in today’s drug pipeline are poorly soluble, which complicates delivery and results in poor bioavailability. Organic solvents, such as ...
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Whether you need to contemporize a well-known but mature brand franchise, expand on an upcoming or recent Rx-to-OTC switch, or broaden the audience appeal of any OTC or VMS product, the strategic use ...
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Poorly joined hard-shell capsules are both visually unappealing and have the potential to leak. A leaking capsule will not have the appropriate fill weight, and its contents may spill onto other ...
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Recently, a Phase I immediate-release solid oral dosage formulation of a pro-drug in gelatin capsules failed to completely dissolve during a three-month accelerated stability study. Scientists at ...
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A systematic approach to solving encapsulation problems caused by a sticky formulation capsule filling This article provides a best-practices approach to troubleshooting capsule-filling problems when ...
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Soft capsules, also called softgels, are one of the most widely used solid oral dosage forms, particularly in the nutraceutical market. Traditional softgels are made from gelatin, but interest in ...
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Annex 15 of the “EU Guidelines for Good Manufacturing Practice for Medicinal Products for Human and Veterinary Use” defines “change control” as: “A formal system by which qualified representatives of ...
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