Articles in this Issue

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  A systematic approach to solving encapsulation problems caused by a sticky formulation

  A systematic approach to solving encapsulation problems caused by a sticky formulation capsule filling This article provides a best-practices approach to troubleshooting capsule-filling problems when ... read more
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  Vegetarian substitutes for gelatin soft capsules

  Soft capsules, also called softgels, are one of the most widely used solid oral dosage forms, particularly in the nutraceutical market. Traditional softgels are made from gelatin, but interest in ... read more
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  Comprehensive Equipment and Utility Change Control for GMP Production Facilities

  Annex 15 of the “EU Guidelines for Good Manufacturing Practice for Medicinal Products for Human and Veterinary Use” defines “change control” as: “A formal system by which qualified representatives of ... read more
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  CDMO Turns to Rotary Granulation Process to Solve Complex Reformulation Challenge

  Recro Gainesville is a contract development and manufacturing organization (CDMO) that provides oral solid dosage (OSD) form development, regulatory support, clinical and commercial manufacturing, and... read more
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  Eye on Excipients: Pharmaceutical Applications for Zein in Film Coating and as an Excipient

  Pharmaceutical and nutraceutical manufacturers are increasingly seeking natural materials to encapsulate active ingredients. read more
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  Orally Disintegrating Tablets: Improving CoQ10 Formulation for Increased Patient Compliance

  Coenzyme Q10 (CoQ10) is an effective antioxidant that plays a fundamental role in cellular bioenergetics, offers cardiac health benefits, and prevents cell damage from free radicals. However, many ... read more
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  A 3-Step Guide to Sourcing Empty Capsules

  There was a time, decades ago, when I could’ve recited the location of nearly every empty-capsule manufacturing plant in the world. These days, I discover new suppliers of empty capsules at a ... read more