Articles in this Issue

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  Formulation: Developing Oral Controlled-Release Drug Products

  July 18, 2019
  Oral controlled-release (OCR) drug products release the active pharmaceutical ingredient (API) into the patient’s gastrointestinal (GI) tract either slowly or after a delay. This results in much of the API being released in an area of higher pH, over... read more
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  Capsules: Using Next-Generation HPMC Polymers as an Alternative to Gelatin for Hard Capsules

  July 18, 2019
  Innovative new drug molecules and technologies have paved the way for promising new therapies to some of the most pressing, life-threatening diseases. The FDA has affirmed that potential by granting fast-track designation to these new drug candidates... read more
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  Orally Disintegrating Tablets: Taste Masking Orally Disintegrating Tablet Formulations

  July 18, 2019
  A significant part of the global population—particularly geriatric, pediatric, and psychiatric patients—has difficulty swallowing solid oral dosage forms (SODFs). Approximately 40 to 60 percent of adults living in assisted- living facilities and ... read more
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  Blending and Tablet Compression: Air Percolation

  July 18, 2019
  When lecturing at pharmaceutical R&D departments and colleges of pharmacy, I am often asked why one batch of a tablet formulation will compress differently from the previous batches. Often, the answer has to do with air trapped in the formulation ... read more
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  Dust Collection: Dust Collection Systems for Dietary Supplement Manufacturing Processes

  July 18, 2019
  A properly-designed dust collection system is a dietary supplement manufacturer’s best defense against cross-contamination, dust accumulation on surfaces, dust explosions and fires, and harm to plant workers . A dust collection system is also ... read more
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  Make it or break it: How tablet design and tooling choice can help or hinder nutraceutical...

  July 18, 2019
  The growing consumer interest in healthy living and natural products has led to an increase in nutraceutical production on a global scale, with market reports projecting that the global nutraceuticals market will grow at an 8.8 percent compound ... read more
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  Continuous Manufacturing: Excipients and Continuous Manufacturing

  July 18, 2019
  Continuous manufacturing of pharmaceutical finished products is now a reality. At this time, pharmaceutical companies are using continuous processes to manufacture four drug products licensed in the US and Europe. They are all solid oral dosage forms... read more
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  Tableting: How Understanding Material Deformation Characteristics Can Improve Tableting Process...

  July 18, 2019
  The tablet is the most popular dosage form for prescribed and over-the-counter medications. Tablets are a simple and convenient way to accurately dose active pharmaceutical ingredients and are flexible enough in their design to address many of the ... read more
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  Current Discussions in Europe Regarding Titanium Dioxide Safety

  July 18, 2019
  Titanium dioxide (TiO2) has safely been used as a pigment in thousands of food and drug products all over the world for more than fifty years. Known in Europe and many other parts of the world as E171, TiO2 is commonly used in solid oral dosage forms... read more