Articles in this Issue

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  Capsule Filling: Making Cap Tucks a Thing of the Past

  January 10, 2020
  Poorly joined hard-shell capsules are both visually unappealing and have the potential to leak. A leaking capsule will not have the appropriate fill weight, and its contents may spill onto other capsules, making them unpleasant for patients to ingest... read more
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  Capsule Filling: Crosslinking in Gelatin Capsules

  January 10, 2020
  Recently, a Phase I immediate-release solid oral dosage formulation of a pro-drug in gelatin capsules failed to completely dissolve during a three-month accelerated stability study. Scientists at Metrics Contract Services were assigned the task of ... read more
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  Drying: Care and Handling of Fluid-Bed Dryer Filters

  January 10, 2019
  Pharmaceutical manufacturers make sizable investments in production equipment, GMP space, validation burden, and quality programs to ensure that they produce their drug products safely, efficiently, and profitably. Manufacturers simply cannot afford ... read more
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  Industry Application: Edible Security Microparticles Protect Daily Wellness Products from Adulteration...

  January 10, 2019
  Founded in 1996, Daily Wellness, Honolulu, HI, manufactures branded, clinically-validated dietary supplements including FertilityBlend natural fertility supplements for men and women and Asensia, a hormone balancing supplement. read more
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  Eye on Excipients: Targeting Gluten Sensitivity in Pharmaceuticals

  January 10, 2019
  Americans with gluten sensitivities have shown increased concern over the years regarding the presence of gluten in foods. Recently, the possibility of gluten in oral medications has been raised as a concern for gluten-sensitive patients. Gluten ... read more
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  Liquid Capsule Filling for Poorly Soluble Drugs

  January 10, 2019
  Hard capsules have traditionally been used to deliver powder or granule formulations, but in recent years, formulators have increasingly used them to deliver oily liquids and semisolid formulations. These lipid-based formulations (LBFs) typically ... read more