Articles in this Issue

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  Selecting the Final SODF: A Comparison of Capsules and Tablets

  January 11, 2018
  Hard capsules, also known as two-piece capsules, offer an extremely versatile drug delivery method. Most are dryfilled with powders, granules, pellets, tablets, or mini-tablets. But hard capsules also accommodate semi-solids— non-aqueous solutions ... read more
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  Abuse-Deterrent Formulation Technologies: Opportunities and Limitations

  January 11, 2018
  Abuse of opioid painkillers in the US is a major problem contributing to an escalating drug overdose epidemic. According to the US Department of Health & Human Services, 12.5 million people misused prescription opioids in 2015, with 2.1 million ... read more
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  Granulation: Scaling up Wet High-Shear Mixer Granulation

  January 11, 2018
  Wet high-shear mixer granulation is a particle size enlargement process in which fine powder is combined with a liquid binder. As the binder is sprayed into the process bowl, the granulator’s impeller and chopper blades shear the powder. The ... read more
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  Industry Application: Rice-Based Excipient Solves PureNSM’s Sticky Situation

  January 11, 2018
  PureNSM (also known as Nutritional Supplement Manufacturers), Chula Vista, CA, is a contract manufacturer of nutritional supplements. It produces more than 900 million capsules per year, usually without using traditional excipients. read more
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  Eye on Excipients: Binding in Wet Granulation

  January 11, 2018
  Wet granulation is one of the most commonly used methods of developing solid dosage drug products. Among the advantages of this classical granulation method over other technologies are a narrow particle size distribution (PSD) of the granules, few ... read more
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  Troubleshooting Common Capsule Defects

  January 11, 2018
  Capsules are fairly easy to fill, but sometimes things go wrong. Here are some tips on how to stop defects. read more