Delves into all aspects of R&D and manufacturing of all oral solid dose (OSD) forms. Tracks industry trends. Relays latest applied research relevant to OSDs. Provides “how to” information for the latest techniques in formulation/excipients, tablet manufacturing, capsule filling and other aspects of the process—including logistics like supply-chain management.
In 2016, the global market for laser marking machines was estimated at $2.21 billion, yet only a handful of lasers are currently used for direct identification of pharmaceuticals. For decades, every ...
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The FDA Safety and Innovation Act was passed by congress in 2012, and the FDA has been working to implement this act ever since. The act authorizes the FDA to establish mutual recognition agreements (...
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Invented in the early 1960s and heralded for its convenience and security, the blister pack was designed to improve medication compliance. Indeed, for the birth-control pill, which became the first ...
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The nutraceutical market has grown swiftly in recent years as the public’s awareness of the nutritional benefits of dietary supplements has increased. Dietary supplements are available across all ...
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The pharmaceutical industry has always been at the forefront of safety practices given the potentially dire consequences of a breach in product purity. Still, counterfeit drug products remain a ...
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Nearly every company that manufactures tablets has had to deal with a sticking problem during compression. Despite the problem’s ubiquitous nature, cross-functional collaborations to discuss sticking ...
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Tablets come in many shapes and sizes, and tablet formulations have a range of physical characteristics and tableting properties, such as abrasiveness, corrosiveness, lubricity, and compressibility. ...
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Hard capsules have traditionally been filled with powders, but they can also be filled with non-aqueous liquids, suspensions, semisolids, thixotropic gels, self-emulsifying drug delivery systems (...
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Softgels have been available since 1935 when Robert Pauli Scherer patented the rotary die encapsulation process. Since then, softgels have been used by the pharmaceutical industry for many ...
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As pharmaceutical manufacturers develop and produce increasing numbers of highly potent active pharmaceutical ingredients (HPAPIs), they also must maintain worker safety. Depending on the level of ...
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The moisture content of excipients plays an important role in the physical and chemical properties of pharmaceutical products. The characteristics of the excipients for a particular dosage of a ...
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Pharmaceutical and nutraceutical production personnel often struggle to achieve the same tablet hardness as that achieved during R&D and sometimes fail to reach even the specified minimum hardness. ...
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Sometimes simple dosing with API powder in a bottle or capsule for a clinical Phase I study can be acceptable, and it may be quicker to use API powder in either a capsule or a bottle than to develop a...
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In recent years, continuous powder mixing has attracted pharmaceutical processing, which has traditionally been a batch-based industry. However, while continuous processing is widely used in bulk ...
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The final rule of the FDA’s Dietary Supplement GMP Regulation 21 CFR Part 111.30(c) requires dietary supplement manufacturers to “routinely calibrate, inspect, or check the equipment to ensure proper ...
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