Delves into all aspects of R&D and manufacturing of all oral solid dose (OSD) forms. Tracks industry trends. Relays latest applied research relevant to OSDs. Provides “how to” information for the latest techniques in formulation/excipients, tablet manufacturing, capsule filling and other aspects of the process—including logistics like supply-chain management.
Over the last two decades, many researchers have sought a better understanding of high-shear granulation. Some have even worked toward finding ways to predict the results of the process, which can ...
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Many of the early papers that addressed capsules made from hydroxypropyl methylcellulose (HPMC), or hypromellose, stated that they didn’t lose their mechanical properties with a reduction in moisture ...
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Liquid fills can deliver active pharmaceutical ingredients (APIs) that are otherwise difficult or impossible to deliver via other solid dosage forms. That has led many research and development ...
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On November 19 last year, the FDA issued public notifications informing consumers that 10 “natural” weight-loss and sexual-enhancement products contained undeclared active pharmaceutical ingredients (...
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The people who formulate and design tablets focus on engineering factors, but the organoleptic aspects were given little if any consideration. Yet organoleptic factors are the key to obtain a positive...
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After tablets, hard capsules are the pharmaceutical industry’s most widely used dosage delivery method. Most capsules are made of gelatin or hypromellose (hydroxypropyl methylcellulose, or HPMC), and ...
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In pharmaceutical applications, CT can help fast-track new product and process development and assess the characteristics of existing products. Tablets and capsules, for example, can be CT-scanned ...
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As pharmaceutical manufacturers seek to fill dwindling pipelines, they are developing new chemistries that are sometimes difficult to stabilize over the desired shelf life. Traditional moisture ...
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During a webinar about capsule filling last year, I asked attendees to choose the most prevalent problem they faced operating their capsule filling process. As Figure 1 shows, the audience—comprising ...
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