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Articles
Issue Archives
July 2020
July 2020
Volume 18 Number 5
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Articles in this Issue
Supply Chain: COVID-19 and the Pharmaceutical Supply Chain
July 09, 2020
A test to the supply chain is almost never the result of a positive event. In the past, the pharmaceutical industry has faced supply chain challenges from fires, floods, wars, and unexpected changes ...
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Tableting: Preventing Powder Binding During Scale-up of a Roller-Compacted Tablet Formulation
July 09, 2020
Roller compaction is a method of dry granulation, in which a dry powder is densified into a solid mass, or compacted ribbon, which is then milled into granules. Roller compaction is often used in ...
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Plant-Based Hard Capsules: A New Era for Patients and Drug Developers
July 09, 2020
Solid oral dosage forms (SODFs) are patients’ preferred way to take medications. According to a 2017 Kiplinger report, eight of the 15 all-time top-selling drug products are SODFs, including the ...
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Content Uniformity: Mitigating Segregation in Batch Feed Systems
July 09, 2020
Drug product developers carefully select excipients based on their function during the manufacturing process or in the final dosage form. Each ingredient must be present in the correct amount to ...
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Nutraceuticals: How to Perform an Out-of-Specification Investigation
July 09, 2020
The establishment of specifications for raw materials, in-process materials, and finished products is one of the essential regulatory requirements of current good manufacturing practices (cGMPs) for ...
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Industry Application: Gravimetric Feeders Support Eli Lilly’s Advancements in Continuous Direct-Compression...
July 09, 2020
Continuous direct compression (CDC) tableting offers several key technical and process advantages over traditional batch tableting processes. First and foremost, it allows the manufacturer to develop ...
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A Common Vocabulary: The Tableting Specification Manual’s Role in an Ever-Changing Industry
July 09, 2020
The Tableting Specification Manual (TSM), published by the American Pharmacists Association (APhA), is the authoritative reference for tablet and tablet tooling specifications in North America.
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What to do if Your Immediate-Release Tablet Scale-up Batch Fails Dissolution
July 09, 2020
Encountering dissolution problems during scale-up of a tablet product can be frustrating and lead to a costly delay in the product’s time to market. However, a careful investigation of the ...
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