Articles in this Issue

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  Supply Chain: COVID-19 and the Pharmaceutical Supply Chain

  July 09, 2020
  A test to the supply chain is almost never the result of a positive event. In the past, the pharmaceutical industry has faced supply chain challenges from fires, floods, wars, and unexpected changes ... read more
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  Tableting: Preventing Powder Binding During Scale-up of a Roller-Compacted Tablet Formulation

  July 09, 2020
  Roller compaction is a method of dry granulation, in which a dry powder is densified into a solid mass, or compacted ribbon, which is then milled into granules. Roller compaction is often used in ... read more
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  Plant-Based Hard Capsules: A New Era for Patients and Drug Developers

  July 09, 2020
  Solid oral dosage forms (SODFs) are patients’ preferred way to take medications. According to a 2017 Kiplinger report, eight of the 15 all-time top-selling drug products are SODFs, including the ... read more
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  Content Uniformity: Mitigating Segregation in Batch Feed Systems

  July 09, 2020
  Drug product developers carefully select excipients based on their function during the manufacturing process or in the final dosage form. Each ingredient must be present in the correct amount to ... read more
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  Nutraceuticals: How to Perform an Out-of-Specification Investigation

  July 09, 2020
  The establishment of specifications for raw materials, in-process materials, and finished products is one of the essential regulatory requirements of current good manufacturing practices (cGMPs) for ... read more
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  Industry Application: Gravimetric Feeders Support Eli Lilly’s Advancements in Continuous Direct-Compression...

  July 09, 2020
  Continuous direct compression (CDC) tableting offers several key technical and process advantages over traditional batch tableting processes. First and foremost, it allows the manufacturer to develop ... read more
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  A Common Vocabulary: The Tableting Specification Manual’s Role in an Ever-Changing Industry

  July 09, 2020
  The Tableting Specification Manual (TSM), published by the American Pharmacists Association (APhA), is the authoritative reference for tablet and tablet tooling specifications in North America. read more
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  What to do if Your Immediate-Release Tablet Scale-up Batch Fails Dissolution

  July 09, 2020
  Encountering dissolution problems during scale-up of a tablet product can be frustrating and lead to a costly delay in the product’s time to market. However, a careful investigation of the ... read more