Articles in this Issue

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  Editor's Message: Full Disclosure

  June 05, 2023
  I have a confession to make: When I joined Tablets & Capsules in January 2022, I’m pretty sure I’d never heard the word “excipient”. If I had, I certainly couldn’t define it nor could I use it in a sentence. read more
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  Re: ‘Sourcing’: Qualifying Excipient Vendors Can Strengthen Supply Chain

  June 05, 2023
  The COVID-19 pandemic caused tremendous supply chain disruptions across practically every industry segment. The pharmaceutical industry was impacted by global trade restrictions as quarantine protocols limited ... read more
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  Encouraging Integration: Fostering Relationships Between Formulators, Specialty Chemical Producers,...

  June 05, 2023
  Pick up the annual report of any generic pharma company like Teva, Sandoz, Aurobindo Pharma, etc. and it will likely include claims about being an integrated pharma company. But really, what does “integration” mean, to ... read more
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  Particle Control: ‘Flows like Water’—and Other Lies We Tell Ourselves

  June 05, 2023
  Perhaps the problem goes back to prehistoric peoples struggling to get their daily grain out of a narrow-mouthed clay pot? Or maybe it began in the Industrial Revolution with the mechanizing of food production and huge ... read more
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  Small Continuity: Applying CM to Wet Granulation and Fluid Bed Drying

  June 05, 2023
  Drug makers have traditionally employed continuous manufacturing for large volumes of a limited number of products. They also prefer direct compression when manufacturing solid dose products continuously. Because of ... read more
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  Making it with (More Than) A Grain of Salt: Novel Mineral Co-Salts Enhance Formulatory Performance

  June 01, 2023
  The use of mineral salts in food, nutritional and pharmaceutical formulations, while common practice, can present some difficulties in production of final dosage tablet and capsule applications. read more
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  Three Steps to Nutra Success: Create Breakthrough Products in a Rapidly Evolving Market

  June 05, 2023
  The nutra numbers don’t lie—the market for supplements is large and growing. For example, 1 out of 4 people worldwide take dietary supplements daily or almost every day,1 and about 77% of consumers have taken a ... read more
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  Lessons Learned: How Can the ‘Nitrosamine Crisis’ Inform Future Formulations?

  June 05, 2023
  Concerns about nitrosamines—which have been known to be carcinogenic since the 1950s—in pharmaceutical finished products (medicines) have been percolating for decades. Nitrosamines are not an intentional part of a ... read more
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  Don’t Fear the CAPA: Addressing ‘Prevention’ Early Leads to Fewer Problems Later

  June 05, 2023
  The US Food and Drug Administration’s acronym for Corrective and Preventive Action (CAPA) can fi ll cGMP manufacturers with dread. Phrases like “death by CAPA” and “ineffective CAPA” are common in the manufacturing world... read more
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  Handling and Micronizing HPAPIs

  June 05, 2023
  There’s no universally agreed definition of what constitutes a highly potent API (HPAPI). But a health-based exposure limit (HBEL) can serve as a more reliable indicator of whether an API is potent or not. However, when ... read more