Delves into all aspects of R&D and manufacturing of all oral solid dose (OSD) forms. Tracks industry trends. Relays latest applied research relevant to OSDs. Provides “how to” information for the latest techniques in formulation/excipients, tablet manufacturing, capsule filling and other aspects of the process—including logistics like supply-chain management.
Sustainability has been a hot topic in the packaging industry and, if models are to be believed, will continue to be so in the future. The global market for sustainable packaging (also known as green ...
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Pharmaceutical manufacturers are increasingly developing new medicines that use highly potent active pharmaceutical ingredients (HPAPIs) and face a growing need for containment solutions that enable ...
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Although traditional batch processing has long been the norm in the pharmaceutical industry, drug product manufacturers have begun to shift toward continuous manufacturing as a more sustainable, ...
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Solid dosage manufacturers and contract packagers typically consider automating manual operations when significant, immediate problems are causing line downtime or when they can no longer tolerate an ...
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A test to the supply chain is almost never the result of a positive event. In the past, the pharmaceutical industry has faced supply chain challenges from fires, floods, wars, and unexpected changes ...
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Roller compaction is a method of dry granulation, in which a dry powder is densified into a solid mass, or compacted ribbon, which is then milled into granules. Roller compaction is often used in ...
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Solid oral dosage forms (SODFs) are patients’ preferred way to take medications. According to a 2017 Kiplinger report, eight of the 15 all-time top-selling drug products are SODFs, including the ...
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Drug product developers carefully select excipients based on their function during the manufacturing process or in the final dosage form. Each ingredient must be present in the correct amount to ...
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The establishment of specifications for raw materials, in-process materials, and finished products is one of the essential regulatory requirements of current good manufacturing practices (cGMPs) for ...
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Continuous direct compression (CDC) tableting offers several key technical and process advantages over traditional batch tableting processes. First and foremost, it allows the manufacturer to develop ...
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The Tableting Specification Manual (TSM), published by the American Pharmacists Association (APhA), is the authoritative reference for tablet and tablet tooling specifications in North America.
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Encountering dissolution problems
during scale-up of a tablet
product can be frustrating and lead
to a costly delay in the product’s
time to market. However, a careful
investigation of the ...
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Sticking is one of the most common problems tablet manufacturers encounter. Sticking describes the buildup of granules on the punch-tip face, which can be caused by several factors, including the ...
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The US is a top spender on healthcare, but many of the drug products that Americans use are produced overseas. Both APIs and other materials, such as capsules, are often sourced from other countries ...
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Water is a critical factor for the physical and chemical stability of solid oral dosage formulations. It is necessary for the growth of microorganisms and can impact a formulation’s stickiness, caking...
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