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Date Published
Capsule Filling: Resolving Weight Variation on Tamping-Style Capsule Fillers
January 14, 2016
During a webinar about capsule filling last year, I asked attendees to choose the most prevalent problem they faced operating their capsule filling process. As Figure 1 shows, the audience—comprising ...
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Computed Tomography: Applications for Evaluating Tablets and Capsules
January 14, 2016
In pharmaceutical applications, CT can help fast-track new product and process development and assess the characteristics of existing products. Tablets and capsules, for example, can be CT-scanned ...
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Stability: Using Sorbents to Ensure Drug Product Integrity and Mitigate Risk
January 14, 2016
As pharmaceutical manufacturers seek to fill dwindling pipelines, they are developing new chemistries that are sometimes difficult to stabilize over the desired shelf life. Traditional moisture ...
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The Quest for Easier-to-Swallow Tablets
January 14, 2016
The people who formulate and design tablets focus on engineering factors, but the organoleptic aspects were given little if any consideration. Yet organoleptic factors are the key to obtain a positive...
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Dissolution Performance of Empty Capsules: Does the Supplier Make a Difference?
January 14, 2016
After tablets, hard capsules are the pharmaceutical industry’s most widely used dosage delivery method. Most capsules are made of gelatin or hypromellose (hydroxypropyl methylcellulose, or HPMC), and ...
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Defending Against Adulteration
June 16, 2016
On November 19 last year, the FDA issued public notifications informing consumers that 10 “natural” weight-loss and sexual-enhancement products contained undeclared active pharmaceutical ingredients (...
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Formulating with Liquids: Two-Piece or Softgel Capsules?
July 14, 2016
Liquid fills can deliver active pharmaceutical ingredients (APIs) that are otherwise difficult or impossible to deliver via other solid dosage forms. That has led many research and development ...
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Capsules: How to Assess and Prevent Brittleness of Hard Gelatin Capsules
January 12, 2017
Capsules have come a long way since they were patented in 1834. Today they are one of the most common and popular means of orally administering pharmaceuticals and dietary supplements. Valued at $1.5 ...
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Rough Going? Tips for Fighting Abrasive Wear of Punches and Dies
January 12, 2017
Manufacturers face several challenges when compressing nutraceutical tablets, many of which are unrefined natural ingredients that are abrasive, corrosive, and/or coarse. It’s thus important to ...
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Elusive Endpoint? Physical Standardization Offers an Alternative
January 12, 2017
Over the last two decades, many researchers have sought a better understanding of high-shear granulation. Some have even worked toward finding ways to predict the results of the process, which can ...
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HPMC Capsules and Hygroscopic Fills: Some Clarification
January 12, 2017
Many of the early papers that addressed capsules made from hydroxypropyl methylcellulose (HPMC), or hypromellose, stated that they didn’t lose their mechanical properties with a reduction in moisture ...
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Good Advice: The Value of Outside Expertise
March 16, 2017
While high-profile CROs, CMOs, and CDMOs consolidate and grow, a cadre of individual consultants soldier on. Tablets & Capsules spoke with several of them about their work.
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How Polymer Science is Changing the Functional Role of Capsules
March 16, 2017
Never have so many drug delivery systems based on hard capsules been available to pharmaceutical manufacturers and physicians. Today, they can choose from a variety of options to achieve immediate, ...
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Eye on Excipients: A Pharmacopeia ‘Standards’ Update
March 16, 2017
Since 1820, the US Pharmacopeial Convention (United States Pharmacopeia, or USP) has published drug standards used in the USA and in more than 140 countries. Additionally, USP produces and supplies ...
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BAT Signal
March 16, 2017
When I began organizing CDMOs into a nonprofit trade association three years ago, I didn’t expect that my short-form response to, “What do you do for a living?” would be, “I’m a lobbyist for the ...
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